Date: May, 27
Preliminary program for the course (PLEASE NOTE THERE MIGHT BE ALTERATIONS)
ONE FULL DAY OF CLASSES, TO BE TAUGHT BY IMEMBERS OF CSSI FORM DIFFERENT COUNTRIES
1. Chaperone concepts - (9-10.30): HARM KAMPINGA
. Basic chaperone reactions and experimental systems to measure such activities. Why cells need chaperones
. Induced resistance (thermotolerance: just phenotypical, excluding HSF-1 regulation)
. HSP families and functional diversity
. Folding-remodeling-proteasomal degradation-autophagosomal degradation
10:30-11:30 Coffee break
2. Heat shock responses - Mechanisms of HSP Stress responses - (11:30-12.15): LEA SISTONEN
. HSF mediated HSP regulation
. Insuline-GF pathway as major regulator of HSF (link with Robert)
. Phenotypes of HSF-knockouts?
. HSP/HSR: development & ageing - (12:15-1.00): ROBERT TANGUAY
. differential regulation of HSP in development
. declined HS response in aging cells
. effects HSP upregulation on longevity
13:00-14:30 LUNCH BREAK
3. The Stress response and disease
. HSP/HSR: cardiovascular disease - (14:30-.15:15): IVOR BENJAMIN
. Role of HSP in ischemia/reperfusion
. Role of HSP in redox status and heart disease
. Role of HSP in AF?
. HSP mutations leading to cardiac diseases
. HSP knockouts and heart diseases
. HSP/HSR: cancer - (15:15-16.00): DANIEL CIOCCA
. Upregulated HSP in cancers
. Functionality of HSP in cancer cell resistance
. HSPs as predictors for (treatment) outcome in human cancers
. HSPs as therapeutic targets in (human) cancer
16:00 -17:00 Coffe break
. UPR mechanisms : role in development & disease - (17:00-18.00): LINDA HENDERSHOT
. Explanation of ER folding machine of the cells
. The 3 branches of the UPR
. ER chaperones: folding and ERAD
. ER/UPR and disease
. Protein aggregation diseases - (18:00-18.30) : HARM KAMPINGA
. Protein aggregation as cause for neurodegenerative diseases
. Role of protein quality control/HSPs in suppression of protein aggregation diseases
. HSP mutations leading to neurodegenerative disease
19:00-20:00 Dinner
NIGHT SESSIONS – these are opportunities for the students to interact with guests and CSSI members , and there will be three sessions, one on the day of the course, and two others, during the meeting.
20:00- Night session Day 1:
Students divide themselves over the 4 subject groups with 2-3 of the speakers of the educational days.
On day 1, they present their poster with their work (obliged to bring for the meeting) to the speakers.
We provide them with feedback, stimulate them to discuss with eachother and in each section, we select one student for a short 10 minute talk on the general meeting (see below)
Night session Day 2:
Just informal chats of students with PIs.
Night session Day 3:
:: Announcement of the winner of the student posteraward
:: Announcement of the winner of the student oral presentation award :: PARTY
